Dr. Shih is an Associate Professor at Seattle Children’s Research Institute and the University of Washington. He received his Ph.D. at the University of British Columbia, in the lab or Dr. Tim Murphy, where his thesis work focused on neuroprotective strategies for ischemic stroke. He then continued with post-doctoral training in the lab of Dr. David Kleinfeld at UC San Diego, where he contributed to development of in vivo two-photon imaging for measurement and manipulation of cerebral microvessels in rodent models. In 2012, Dr. Shih started an independent research laboratory in Charleston at the Medical University of South Carolina, where he established a research program to use advanced optical imaging techniques to study cerebrovascular disease. He then moved to Seattle Children’s Research Institute in 2018. The research performed by his team has led to new discoveries related to the consequence of small-scale stroke, mechanisms of neurovascular coupling, and regulation of blood flow through brain capillaries by pericytes. He seeks to obtain a clear understanding the basic biology underlying vascular physiology, and then layer on the complexities of factors involved in human disease, to identify targets and approaches for disease treatment. Dr. Shih’s work has been funded through major grants from the National Institutes of Health (NINDS and NIA), and also through foundation grants from the Dana Foundation, American Heart Association, Alzheimer’s Association, A New Vision award, Albert Trust and others.


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Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute

Dept. of Pediatrics and Bioengineering, University of Washington