Literature reviews on vascular dementia tend to have an “arterio-centric” view of vascular roles in disease progression. Indeed, atheroclerosis, arteriolosclerosis and cerebral amyloid angiopathy affect brain arteries and arterioles...
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Mural cells cover the vasculature and control numerous aspects of vascular function, including control of blood flow, vessel growth/integrity, scar formation, and even regulation of inflammation. However, the term “mural cell” is an...
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About 40% of children with sickle cell disease develop small strokes visible by MRI, commonly referred to as silent cerebral infarcts. Some of these strokes are tiny, and fall in the size range of microinfarcts, a type of brain lesion that is...
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A new paper from our lab shows that microinfarcts induce prolonged dysfunction in brain areas estimated to be 12-times larger than the visible injury site. Data from c-Fos assays and in vivo hemodynamic imaging reveal how individually miniscule...
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A study from our lab provides strong evidence that pericytes are a primary locus of matrix-mellaproteinase-9-dependent (MMP-9) capillary damage and blood leakage during ischemia. Read the Full Article on Eureka Alert
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