We have moved to the Seattle Children’s Research Institute in Seattle, Washington, and are excited to join the Center for Developmental...
Read moreThe Shih lab has moved to Seattle!
Pericyte plasticity and cerebrovascular health
Pericytes are a beautiful cell type to study. They come in a variety of shapes and sizes. The most elegant forms drape along the capillary bed...
Read moreThe ins and outs of brain plumbing during dementia
Literature reviews on vascular dementia tend to have an “arterio-centric” view of vascular roles in disease progression. Indeed, ...
Read moreUnderstanding Brain Mural Cells
Mural cells cover the vasculature and control numerous aspects of vascular function, including control of blood flow, vessel growth/integrity...
Read moreSmall Strokes in Sickle Cell Disease
About 40% of children with sickle cell disease develop small strokes visible by MRI, commonly referred to as silent cerebral infarcts. Some of...
Read moreChase’s going away party
Dinner at Bowen’s Island to send Chase Burton off to Grad School. Good luck Chase! Come back if you feel the urge to wiggle some mouse...
Read moreThe lasting effects of ministrokes may contribute to dementia
A new paper from our lab shows that microinfarcts induce prolonged dysfunction in brain areas estimated to be 12-times larger than the visible...
Read moreAdvanced imaging of intact brains during ischemic stroke reveals a new role for pericytes
A study from our lab provides strong evidence that pericytes are a primary locus of matrix-mellaproteinase-9-dependent (MMP-9) capillary...
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