206-884-1314
Andy.Shih@SeattleChildrens.org
Cerebal Microinfarcts
Modelling the Smallest Strokes
Brain Microvessel Imaging
The Neurovascular Unit and Brain Injury
Stroke Injury and Recovery
Imaging How Brain Circuits Remodel

What we do

Our research focuses on the small blood vessels that delivery oxygen and nutrients to all reaches of the brain. In the human brain, an estimated 100,000 miles of blood vessels delivers blood to 100 billion neurons. This immensely complex task can easily go awry during human disease. When we are young, genetic and environmental factors can compromise the normal development of brain vasculature. As we age, leakage and blockage of small vessels can contribute to Alzheimer’s disease and vascular dementia. Our laboratory studies how blood vessels grow, degrade, and respond to injury from birth to senescence. We hope that our research will yield new ways to reduce to improve cerebrovascular function in brain diseases that affect both children and adults.

meet the team

We are brain imagers

Andy Shih, Ph.D.
Andy Shih, Ph.D.
Principal Investigator & Associate Professor
Seattle Children’s Research Institute & University of Washington
Andree-Anne Berthiaume
Andree-Anne Berthiaume
Ph.D. Candidate
Pericyte Structural Plasticity in the Young and Aged Brain
Stefan Stamenkovic, Ph.D.
Stefan Stamenkovic, Ph.D.
Post-doctoral Fellow
Microvascular Structure and Function in Cerebral White Matter
Vanessa Coelho-Santos, Ph.D.
Vanessa Coelho-Santos, Ph.D.
Post-doctoral Fellow
Post-natal Development of the Blood-brain Barrier

Lab Updates

Q & A with the Dana Foundation

Q & A with the Dana Foundation

Dr. Shih recently chatted with Kayt Sukel from the Dana Foundation for a Q & A. The Dana Foundation David Mahoney Neuroimaging Award was the first major grant...

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Seattle Children’s article on our research by Jennifer Carson

Seattle Children’s article on our research by Jennifer Carson

Dr. Andy Shih hopes to solve the mystery of microinfarcts — small, asymptomatic strokes that often occur undetected. Learn about how Andy’s research uses innovative...

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JCBFM Cover!

JCBFM Cover!

We are lucky to be selected for JCBFM cover three times in the last few years! For this months issue, our paper on pericyte organization and structural diversity in...

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