206-884-1314
Andy.Shih@SeattleChildrens.org
Cerebal Microinfarcts
Modelling the Smallest Strokes
Brain Microvessel Imaging
The Neurovascular Unit and Brain Injury
Stroke Injury and Recovery
Imaging How Brain Circuits Remodel

What we do

Our research focuses on the small blood vessels that delivery oxygen and nutrients to all reaches of the brain. In the human brain, an estimated 100,000 miles of blood vessels delivers blood to 100 billion neurons. This immensely complex task can easily go awry during human disease. When we are young, genetic and environmental factors can compromise the normal development of brain vasculature. As we age, leakage and blockage of small vessels can contribute to Alzheimer’s disease and vascular dementia. Our laboratory studies how blood vessels grow, degrade, and respond to injury from birth to senescence. We hope that our research will yield new ways to reduce to improve cerebrovascular function in brain diseases that affect both children and adults.

meet the team

We are brain imagers

Andy Shih, Ph.D.
Andy Shih, Ph.D.
Principal Investigator & Associate Professor
Seattle Children’s Research Institute & University of Washington
Andree-Anne Berthiaume
Andree-Anne Berthiaume
Ph.D. Candidate
Pericyte Structural Plasticity in the Young and Aged Brain
Stefan Stamenkovic, Ph.D.
Stefan Stamenkovic, Ph.D.
Post-doctoral Fellow
Microvascular Structure and Function in Cerebral White Matter
Vanessa Coelho-Santos, Ph.D.
Vanessa Coelho-Santos, Ph.D.
Post-doctoral Fellow
Postnatal Development of the Blood-brain Barrier

Lab Updates

Sneak Preview: New Review on Development of Brain Vasculature

Sneak Preview: New Review on Development of Brain Vasculature

Dr. Vanessa Coelho-Santos is working on a new invited review for WIRES Developmental Biology (in second review). Data from numerous papers were compiled to paint the...

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Summer Time in the City!

Summer Time in the City!

A busy lab this summer! The lab welcomes new post-doctoral fellow Dr. Stephanie Bonney, a recent grad of Prof. Julie Siegenthaler at U. Colorado. She will work on...

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Lab receives pilot grant to image pericytes in white matter

Lab receives pilot grant to image pericytes in white matter

In the metropolis that is our brain, the gray matter represents the buildings, and the white matter represents the wires that connect them all together...

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