206-884-1314
Andy.Shih@SeattleChildrens.org
Cerebal Microinfarcts
Modelling the Smallest Strokes
Brain Microvessel Imaging
The Neurovascular Unit and Brain Injury
Stroke Injury and Recovery
Imaging How Brain Circuits Remodel

What we do

Our research focuses on the small blood vessels that delivery oxygen and nutrients to all reaches of the brain. In the human brain, an estimated 400 miles of blood vessels delivers blood to 100 billion neurons. This immensely complex task can easily go awry during human disease. When we are young, genetic and environmental factors can compromise the normal development of brain vasculature. As we age, leakage and blockage of small vessels can contribute to Alzheimer’s disease and vascular dementia. Our laboratory studies how blood vessels grow, degrade, and respond to injury from birth to senescence. We hope that our research will yield new ways to reduce to improve cerebrovascular function in brain diseases that affect both children and adults.

meet the team

We are brain imagers

Andy Shih, Ph.D.
Andy Shih, Ph.D.
Principal Investigator
Associate Professor
Maria Sosa
Maria Sosa
Research Technician
Perivascular cells in small vessel disease
AJ Cruz
AJ Cruz
Research Technician
Cerebrovascular development
Cara Nielson
Cara Nielson
Graduate Student
Mechanisms of pericyte remodeling
Lila Faulhaber
Lila Faulhaber
Research Technician
Cerebrovascular dysfunction associated with CAR-T cell therapy-induced neurotoxicity
Liam Sullivan
Liam Sullivan
Research Technician
Mouse tools for pericyte imaging
Taryn Tieu
Taryn Tieu
Research Technician
Microglial dynamics in the developing and adult brain
Stephanie Bonney, Ph.D.
Stephanie Bonney, Ph.D.
Post-doctoral Fellow
Behaviors of perivascular cells in small vessel disease and ischemia
Stefan Stamenkovic, Ph.D.
Stefan Stamenkovic, Ph.D.
Post-doctoral Fellow
Microvascular structure and function in gray and white matter
Vanessa Coelho-Santos, Ph.D.
Vanessa Coelho-Santos, Ph.D.
Post-doctoral Fellow
Construction of brain capillary networks during postnatal development

Lab Updates

Cara Nielson joins the lab!

Cara Nielson joins the lab!

We are excited to welcome Cara Nielson to the lab!  Cara is a graduate student in the Neuroscience program at the University of Washington. She’s interested in...

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New insights provided by 3-D electron microscopy

New insights provided by 3-D electron microscopy

We recently published a study that examines the physical interaction between the two cell types that make up capillaries throughout the body: Pericytes and...

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Cooking Party

Cooking Party

Inspired an online cooking class from Hot Stove Society, we did a lab cooking party to celebrate recent graduation of Andree-Anne Berthiaume and Sharon Ornelas. Jap...

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