206-884-1314
Andy.Shih@SeattleChildrens.org
Cerebal Microinfarcts
Modelling the Smallest Strokes
Brain Microvessel Imaging
The Neurovascular Unit and Brain Injury
Stroke Injury and Recovery
Imaging How Brain Circuits Remodel

What we do

Our research focuses on the small blood vessels that delivery oxygen and nutrients to all reaches of the brain. In the human brain, an estimated 100,000 miles of blood vessels delivers blood to 100 billion neurons. This immensely complex task can easily go awry during human disease. When we are young, genetic and environmental factors can compromise the normal development of brain vasculature. As we age, leakage and blockage of small vessels can contribute to Alzheimer’s disease and vascular dementia. Our laboratory studies how blood vessels grow, degrade, and respond to injury from birth to senescence. We hope that our research will yield new ways to reduce to improve cerebrovascular function in brain diseases that affect both children and adults.

meet the team

We are brain imagers

Andy Shih, Ph.D.
Andy Shih, Ph.D.
Associate Professor
Principal Investigator and Associate Professor
Sharon Ornelas
Sharon Ornelas
Research tecnician
Ultrastructural analysis of pericyte-endothelial interactions
Madeline Kilby
Madeline Kilby
Research technician
Pericytes and matrix metalloprotease responses in vascular injury
Stephanie Bonney, Ph.D.
Stephanie Bonney, Ph.D.
Post-doctoral Fellow
Behaviors of perivascular cells in small vessel disease and ischemia
Andree-Anne Berthiaume
Andree-Anne Berthiaume
Ph.D. Candidate
Pericyte Structural Plasticity in the Young and Aged Brain
Stefan Stamenkovic, Ph.D.
Stefan Stamenkovic, Ph.D.
Post-doctoral Fellow
Microvascular Structure and Function in Cerebral White Matter
Vanessa Coelho-Santos, Ph.D.
Vanessa Coelho-Santos, Ph.D.
Post-doctoral Fellow
Postnatal Development of the Blood-brain Barrier

Lab Updates

Vanessa Receives Post-doctoral Fellowship from the American Heart Association!

Vanessa Receives Post-doctoral Fellowship from the American Heart Association!

Congrats to Vanessa Coelho-Santos for winning a prestigious AHA fellowship for her project: Imaging Development of Brain Microvascular Networks Under Normoxia and...

Read more
Vanessa and Andree-Anne Win Awards at Local Symposium!

Vanessa and Andree-Anne Win Awards at Local Symposium!

Every year, the Seattle Children’s Research Institute holds a student and post-doc symposium to highlight the exciting and diverse research done at the...

Read more
An exciting visit to University of South Florida

An exciting visit to University of South Florida

Thanks to Jerry Breslin for an invitation to speak at the USF Molecular Pharmacology and Physiology Seminar In Tampa Bay, Florida. A wonderful group of...

Read more