206-884-1314
Andy.Shih@SeattleChildrens.org
Cerebal Microinfarcts
Modelling the Smallest Strokes
Brain Microvessel Imaging
The Neurovascular Unit and Brain Injury
Stroke Injury and Recovery
Imaging How Brain Circuits Remodel

What we do

Our research focuses on the small blood vessels that delivery oxygen and nutrients to all reaches of the brain. In the human brain, an estimated 400 miles of blood vessels delivers blood to 100 billion neurons. This immensely complex task can easily go awry during human disease. When we are young, genetic and environmental factors can compromise the normal development of brain vasculature. As we age, leakage and blockage of small vessels can contribute to Alzheimer’s disease and vascular dementia. Our laboratory studies how blood vessels grow, degrade, and respond to injury from birth to senescence. We hope that our research will yield new ways to reduce to improve cerebrovascular function in brain diseases that affect both children and adults.

meet the team

We are brain imagers

Andy Shih, Ph.D.
Andy Shih, Ph.D.
Principal Investigator
Associate Professor
Lila Faulhaber
Lila Faulhaber
Research Technician
Cerebrovascular dysfunction associated with CAR-T cell therapy-induced neurotoxicity
Liam Sullivan
Liam Sullivan
Research Technician
Pericytes and matrix metalloprotease responses in vascular injury
Sharon Ornelas
Sharon Ornelas
Research Technician
Ultrastructural analysis of pericyte-endothelial interactions
Taryn Tieu
Taryn Tieu
Research Technician
Cerebrovascular development
Stephanie Bonney, Ph.D.
Stephanie Bonney, Ph.D.
Post-doctoral Fellow
Behaviors of perivascular cells in small vessel disease and ischemia
Andree-Anne Berthiaume
Andree-Anne Berthiaume
Ph.D. Candidate
Pericyte Structural Plasticity in the Young and Aged Brain
Stefan Stamenkovic, Ph.D.
Stefan Stamenkovic, Ph.D.
Post-doctoral Fellow
Microvascular Structure and Function in Cerebral White Matter
Vanessa Coelho-Santos, Ph.D.
Vanessa Coelho-Santos, Ph.D.
Post-doctoral Fellow
Postnatal Development of the Blood-brain Barrier

Lab Updates

Practical guide to live imaging of brain pericytes

Practical guide to live imaging of brain pericytes

We’ve written a guide to imaging and manipulation of brain pericytes using two-photon microscopy. It includes everything from how to identify mural cell types...

Read more
Stephanie Bonney receives F32 award!

Stephanie Bonney receives F32 award!

Post-doctoral fellow, Stephanie Bonney, has won an F32 award from the NINDS to elucidate the role of perivascular fibroblasts in ischemic injury. Congrats...

Read more
David Hartmann receives Distinguished Graduate Award

David Hartmann receives Distinguished Graduate Award

Recent MD/PhD Graduate, David Hartmann, has won a Distinguished Graduate Student Award from the Medical University of South Carolina. He gave a remote talk to...

Read more