843-876-1868
shiha@musc.edu
Cerebal Microinfarcts
Modelling the Smallest Strokes
Brain Microvessel Imaging
The Neurovascular Unit and Brain Injury
Stroke Injury and Recovery
Imaging How Brain Circuits Remodel

What we do

Our research focuses on the small blood vessels that delivery oxygen and nutrients to all reaches of the brain. In the human brain, an estimated 100,000 miles of blood vessels delivers blood to 100 billion neurons. This immensely complex task can easily go awry during human disease. When we are young, genetic and environmental factors can compromise the normal development of brain vasculature. As we age, leakage and blockage of small vessels can contribute to Alzheimer’s disease and vascular dementia. Our laboratory studies how blood vessels grow, degrade, and respond to injury from birth to senescence. We hope that our research will yield new ways to reduce to improve cerebrovascular function in brain diseases that affect both children and adults.

meet the team

We are brain imagers

Andy Shih, Ph.D.
Andy Shih, Ph.D.
Principal Investigator
Assistant Professor in the Department of Neuroscience.
Manuel Levy, Ph.D.
Manuel Levy, Ph.D.
Research Assistant Professor
Imaging Synaptic Plasticity During Stroke Recovery.
David Hartmann
David Hartmann
M.D./Ph.D. Student
The Role of Cerebral Pericytes in Blood Flow Control.
Robert Underly
Robert Underly
Ph.D. Candidate
Pericyte Roles in Blood-Brain Barrier Dysfunction during Stroke.
Andrée-Anne Berthiaume
Andrée-Anne Berthiaume
Ph.D. Candidate
Pericyte Structural Plasticity and Blood-Brain Barrier Function.
Ian Grant
Ian Grant
Research Specialist
Imaging Small Vessel Disease in Post Mortem Human Brain Tissue.
Chase Burton
Chase Burton
Research Assistant
Microinfarcts and Spreading Depression.
Ashley Watson
Ashley Watson
Research Assistant
Microvascular Flow in the Aging Brain.

Lab Updates

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Understanding Brain Mural Cells

Mural cells cover the vasculature and control numerous aspects of vascular function, including control of blood flow, vessel growth/integrity, scar formation, and...

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Small Strokes in Sickle Cell Disease

About 40% of children with sickle cell disease develop small strokes visible by MRI, commonly referred to as silent cerebral infarcts. Some of these strokes are tiny...

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Chase’s going away party

Dinner at Bowen’s Island to send Chase Burton off to Grad School.  Good luck Chase! Come back if you feel the urge to wiggle some mouse whiskers.

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